Acetylcholinesterase

Acetylcholinesterase is thought to be inhibited at the lower temperature, and this is the basis for this diagnostic test.

After release acetylcholine is broken down by the enzyme acetylcholinesterase Like many other biologically active substances, acetylcholine exerts its effects by binding to and activating receptors located on the surface of cells.

Nerve agents disrupt the nervous system by inhibiting the function of the enzyme acetylcholinesterase by forming a covalent bond where acetylcholine would break down (undergoes hydrolysis ).

Nonradioactive northern blotting for the determination of acetylcholinesterase mRNA.

Once the impulse is sent, the enzyme acetylcholinesterase immediately breaks down the acetylcholine in order to allow the muscle or organ to relax.

They allow endogenously released acetylcholine more time to interact with its respective receptor before being inactivated by acetylcholinesterase in the synaptic cleft (the space between nerve and muscle).

Usually, acetylcholinesterase inhibitors are started at a low dose and increased until the desired result is achieved.