Chloramphenicol is an English word with synonyms like antibiotic. Below you'll find 10+ example sentences showing how it's used in practice.
Chloramphenicol in a sentence
Chloramphenicol meaning
A broad-spectrum antibiotic C₁₁H₁₂Cl₂N₂O₅ isolated from cultures of a soil actinomycete (Streptomyces venezuelae) or prepared synthetically and used against serious infections such as typhoid fever.
Synonyms of Chloramphenicol
Using Chloramphenicol
- The main meaning on this page is: A broad-spectrum antibiotic C₁₁H₁₂Cl₂N₂O₅ isolated from cultures of a soil actinomycete (Streptomyces venezuelae) or prepared synthetically and used against serious infections such as typhoid fever.
- Useful related words include: chloromycetin, antibiotic, antibiotic drug.
- In the example corpus, chloramphenicol often appears in combinations such as: chloramphenicol is, to chloramphenicol, of chloramphenicol.
Context around Chloramphenicol
- Average sentence length in these examples: 20.7 words
- Position in the sentence: 6 start, 8 middle, 4 end
- Sentence types: 18 statements, 0 questions, 0 exclamations
Corpus analysis for Chloramphenicol
- In this selection, "chloramphenicol" usually appears in the middle of the sentence. The average example has 20.7 words, and this corpus slice is mostly made up of statements.
- Around the word, pure, level, oral, resistance, associated and dose stand out and add context to how "chloramphenicol" is used.
- Recognizable usage signals include a problem chloramphenicol succinate ester and because pure chloramphenicol does not. That gives this page its own corpus information beyond isolated example sentences.
- By corpus frequency, "chloramphenicol" sits close to words such as aav, abdicating and abductor, which helps place it inside the broader word index.
Example types with chloramphenicol
The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:
No difference in bioavailability is noted between chloramphenicol and CPE. (10 words)
In liver impairment, the dose of chloramphenicol must therefore be reduced. (11 words)
Currently, some Enterococcus faecium and Pseudomonas aeruginosa strains are resistant to chloramphenicol. (12 words)
This creates a problem: Chloramphenicol succinate ester is an inactive prodrug and must first be hydrolysed to chloramphenicol; however, the hydrolysis process is often incomplete, and 30% of the dose is lost and removed in the urine. (37 words)
Its use near the end of pregnancy and during breastfeeding is typically not recommended. citation Chloramphenicol is a broad-spectrum antibiotic that typically stops bacterial growth by stopping the production of proteins. (32 words)
It is easy to select for reduced membrane permeability to chloramphenicol in vitro by serial passage of bacteria, and this is the most common mechanism of low-level chloramphenicol resistance. (30 words)
Example sentences (18)
Intravenous The intravenous (IV) preparation of chloramphenicol is the succinate ester, because pure chloramphenicol does not dissolve in water.
It is easy to select for reduced membrane permeability to chloramphenicol in vitro by serial passage of bacteria, and this is the most common mechanism of low-level chloramphenicol resistance.
Manufacture of oral chloramphenicol in the U.S. stopped in 1991, because the vast majority of chloramphenicol-associated cases of aplastic anaemia are associated with the oral preparation.
The majority of the chloramphenicol dose is excreted by the kidneys as the inactive metabolite, chloramphenicol glucuronate.
This creates a problem: Chloramphenicol succinate ester is an inactive prodrug and must first be hydrolysed to chloramphenicol; however, the hydrolysis process is often incomplete, and 30% of the dose is lost and removed in the urine.
Further research confirmed the significant role of ·OH and in the degradation of norfloxacin and chloramphenicol by studying the effects of plasma-generated reactive oxygen/nitrogen species.
Particles obtained from solutions in which the concentration of noni extract was 25 microliters showed better results, comparable to chloramphenicol.
Chemotherapeutic Drugs Chapter 44. Chloramphenicol, Tetracyclines, Macrolides, Clindamycin, & Streptogramins but the mechanism is not fully understood.
Currently, some Enterococcus faecium and Pseudomonas aeruginosa strains are resistant to chloramphenicol.
In liver impairment, the dose of chloramphenicol must therefore be reduced.
Its use near the end of pregnancy and during breastfeeding is typically not recommended. citation Chloramphenicol is a broad-spectrum antibiotic that typically stops bacterial growth by stopping the production of proteins.
Neurotoxic reactions Headache, mild depression, mental confusion, and delirium have been described in patients receiving chloramphenicol.
No difference in bioavailability is noted between chloramphenicol and CPE.
No standard dose reduction exists for chloramphenicol in liver impairment, and the dose should be adjusted according to measured plasma concentrations.
Only a tiny fraction of the chloramphenicol is excreted by the kidneys unchanged.
Pharmacokinetics Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule.
Resistance As resistance to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, and streptomycin is now common, these agents have not been used as first–line treatment of typhoid fever for almost 20 years.
The topical formulation of chloramphenicol was commonly used as eye drops as first-line treatment of conjunctivitis.
Common combinations with chloramphenicol
These word pairs occur most frequently in English texts:
- chloramphenicol is 4×
- to chloramphenicol 4×
- of chloramphenicol 3×
- chloramphenicol in 3×
- the chloramphenicol 2×