Dopaminergic

In primates, dopaminergic neuron activity increases in the nigrostriatal pathway when a new stimulus is presented. citation Dopaminergic activity decreases with repeated stimulus presentation.

Altogether, these results argue for an alteration of the nigrostriatal dopaminergic pathway in MeCP2-deficient animals as a contributor of the neuromotor deficits.

An excess in dopaminergic signalling is hypothesized to be linked to the positive symptoms of psychosis, especially those of schizophrenia.

Dopaminergic neurons (dopamine-producing nerve cells) are comparatively few in number—a total of around 400,000 in the human brain citation —and their cell bodies are confined in groups to a few relatively small brain areas.

Dopaminergic projections from the ventral tegmental area (bottom part of the "midbrain" or mesencephalon) to the prefrontal cortex (mesocortical pathway) and to the nucleus accumbens (mesolimbic pathway - "meso" referring to "from the mesencephalon"..

Green arrows refer to excitatory glutamatergic pathways, red arrows refer to inhibitory GABAergic pathways and turquoise arrows refer to dopaminergic pathways that are excitatory on the direct pathway and inhibitory on the indirect pathway.

However, cocaine is more active in the dopaminergic neurons of the ventral tegmental area than the substantia nigra.

However, some contributions to the unique susceptibility of dopaminergic neurons in the pars compacta have been identified.

In any case, there is nonetheless a good deal of evidence to indicate that modafinil is producing at least a portion of its wakefulness-promoting effects by acting as a DRI, or at least via activation of the dopaminergic system.

In Parkinson's disease, a disorder that affects neuromotor functioning, there is decreased neuromelanin in the substantia nigra and locus coeruleus as consequence of specific dropping out of dopaminergic and noradrenergic pigmented neurons.

The advantage to using these types of patients is that dopaminergic projections to the prefrontal cortex are more likely to be intact.

The cause of bruxism itself is not completely understood, but psychosocial factors appear to be implicated in awake bruxism and dopaminergic dysfunction and other central nervous system mechanisms may be involved in sleep bruxism.

The dopaminergic pathway from the substantia nigra pars compacta to the striatum is shown in light blue.

The drawback of levodopa treatment is that it treats the symptoms of Parkinson's (low dopamine levels), rather than the cause (the death of dopaminergic neurons in the substantia nigra).

Tianeptine : Enhances the reuptake of serotonin and increases dopaminergic and glutamatergic neurotransmission.