Wondering how to use Gpcr in a sentence? Below are 10+ example sentences from authentic English texts. Including the meaning .
Gpcr meaning
Initialism of G protein–coupled receptor.
Using Gpcr
- The main meaning on this page is: Initialism of G protein–coupled receptor.
- In the example corpus, gpcr often appears in combinations such as: the gpcr, gpcr signaling, are gpcr.
Context around Gpcr
- Average sentence length in these examples: 22.1 words
- Position in the sentence: 3 start, 10 middle, 4 end
- Sentence types: 17 statements, 0 questions, 0 exclamations
Corpus analysis for Gpcr
- In this selection, "gpcr" usually appears in the middle of the sentence. The average example has 22.1 words, and this corpus slice is mostly made up of statements.
- Around the word, receptor, weakening, process, signaling, reorganizes and cellular stand out and add context to how "gpcr" is used.
- Recognizable usage signals include 3 are gpcr and 1 and a gpcr can trigger. That gives this page its own corpus information beyond isolated example sentences.
- By corpus frequency, "gpcr" sits close to words such as aav, abdicating and abductor, which helps place it inside the broader word index.
Example types with gpcr
The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:
In addition, the GPCR may be desensitized itself. (8 words)
As a result, the GPCR reorganizes to allow activation of G-alpha proteins. (13 words)
Integrins are shown elevating Ca 2+ and phosphorylating FAK, which is weakening GPCR signaling. (14 words)
However, the binding of any single particular agonist may also initiate activation of multiple different G-proteins, as it may be capable of stabilizing more than one conformation of the GPCR’s GEF domain, even over the course of a single interaction. (42 words)
Regardless of these various nuances, the GPCR’s preferred coupling partner is usually defined according to the G-protein most obviously activated by the endogenous ligand under most physiological and/or experimental conditions. (33 words)
The side perspective is a view from above and to the side of the GPCR as it is set in the plasma membrane (the membrane lipids have been omitted for clarity). (31 words)
Example sentences (17)
A GPCR can trigger diverse events in the cell, such as division, relocation, or even death.
As a result, the GPCR reorganizes to allow activation of G-alpha proteins.
Glutamate receptors are one of four categories, three of which are ligand-gated ion channels and one of which is a G-protein coupled receptor (often referred to as GPCR).
GPCR cellular regulation Receptor desensitization is mediated through a combination phosphorylation, β-arr binding, and endocytosis as described above.
G-protein-coupled receptor kinases (GRKs) are key modulators of G-protein-coupled receptor (GPCR) signaling.
However, the binding of any single particular agonist may also initiate activation of multiple different G-proteins, as it may be capable of stabilizing more than one conformation of the GPCR’s GEF domain, even over the course of a single interaction.
In addition, the GPCR may be desensitized itself.
Integrins are shown elevating Ca 2+ and phosphorylating FAK, which is weakening GPCR signaling.
It is known that in the inactive state, the GPCR is bound to a heterotrimeric G protein complex.
Of the four 5-HT receptor classes, 3 are GPCR and 1 is ligand gated cation channel.
Regardless of these various nuances, the GPCR’s preferred coupling partner is usually defined according to the G-protein most obviously activated by the endogenous ligand under most physiological and/or experimental conditions.
The largest class by far is class A, which accounts for nearly 85% of the GPCR genes.
There may even be specific proteins of these classes whose primary function is as part of GPCR-independent pathways, termed Activators of G-protein Signalling (AGS).
The side perspective is a view from above and to the side of the GPCR as it is set in the plasma membrane (the membrane lipids have been omitted for clarity).
The three main pathways that lead to its activation are GPCR pathways, RTK pathways, and gated ion channels; it regulates proteins either directly or by binding to an enzyme.
Thus, even at this early stage in the process, GPCR-initiated signaling has the capacity for self-termination.
When the subtype activated depends on the ligand that is bound to the GPCR, this is called functional selectivity (also known as agonist-directed trafficking, or conformation-specific agonism).
Common combinations with gpcr
These word pairs occur most frequently in English texts: