Immunogenicity

The exposure pattern is consistent throughout multiple cycles of treatment without any attenuation of PK parameters, supporting the premise that there is no evidence of clinically relevant immunogenicity.

Kim's team also increased the spike protein's immunogenicity and stabilized it by, respectively, chopping off a chunk of it and making a couple of chemical substitutions in the molecule.

The Indian drug maker, in a release, said this will be a multi-center and randomized controlled study, which will include safety and immunogenicity study.

The purpose of this protocol is not that much to study the immunogenicity and safety of the vaccine, that goes without saying.

We plan to explore the pharmacokinetic ("PK") profile, pharmacodynamic ("PD") profile, and immunogenicity, of AP- PA02.

We will conduct a clinical trial and see how this combination works in terms of safety, immunogenicity and protectivity,” he said.

The nature of the central TCR-exposed residues of MHC-bound peptides is associated with peptide immunogenicity.