Insertional

Insertional mutagenesis main Transposons and viruses may insert DNA sequence into coding regions or functional elements of a gene and result in inactivation of the gene.

Sometimes the insertion of a TE into a gene can disrupt that gene's function in a reversible manner, in a process called insertional mutagenesis ; transposase-mediated excision of the DNA transposon restores gene function.

This gives rise to a concern that insertional mutagenesis due to integration into the host genome might lead to cancer or leukemia.