Integrins in a sentence

Integrins carrying this domain either bind to collagens (e.g. integrins α1 β1, and α2 β1), or act as cell-cell adhesion molecules (integrins of the β2 family).

The repertoire of integrins expressed on a particular cell can specify the signaling pathway due to the differential binding affinity of ECM ligands for the integrins.

Attachment of cell to the ECM Integrins couple the ECM outside a cell to the cytoskeleton (in particular, the microfilaments ) inside the cell.

Focal adhesions are large molecular complexes, which are generated following interaction of integrins with ECM, then their clustering.

Gene knockouts of integrins in mice are not always lethal, which suggests that during embryonal development, one integrin may substitute its function for another in order to allow survival.

Important differences exist between integrin-signalling in circulating blood cells and non-circulating cells such as epithelial cells ; integrins of circulating cells are normally inactive.

Integrins are not simply hooks, but give the cell critical signals about the nature of its surroundings.

Integrins can assume several different well-defined shapes or "conformational states".

Integrins can regulate the receptor tyrosine kinase signaling by recruiting specific adaptors to the plasma membrane.

Knowledge of the relationship between integrins and receptor tyrosine kinase has laid a foundation for new approaches to cancer therapy.

Multisubunit transmembrane receptors called integrins are used to bind to the ECM.

Perhaps the most convincing evidence involves the use of antibodies that only recognize integrins when they have bound to their ligands, or are activated.

Signal transduction Integrins play an important role in cell signaling by modulating the cell signaling pathways of transmembrane protein kinases such as receptor tyrosine kinases (RTK).

The cations in the β subunits are more interesting: they are directly involved in coordinating at least some of the ligands that integrins bind.

The integrins thus serve to link two networks across the plasma membrane: the extracellular ECM and the intracellular actin filamentous system.

There are several types of integrins, and a cell may have several types on its surface.

There are various ways of categorizing the integrins.

These integrins are concentrated on cells of the vasculature and on some types of tumor cells, which in part explains the proangiogenic effects of iodothyronines and proliferative actions of thyroid hormone on some cancers including gliomas.

Those integrins that don't carry this inserted domain also have an A-domain in their ligand binding site, but this A-domain is found on the β subunit.

Thus integrins lie at the heart of many cellular biological processes.