Lactam is an English word. Below you'll find 10+ example sentences showing how it's used in practice.
Lactam meaning
Any of a class of cyclic amides that are the nitrogen analogs of lactones, formed by heating amino acids; the tautomeric enol forms are known as lactims.
Using Lactam
- The main meaning on this page is: Any of a class of cyclic amides that are the nitrogen analogs of lactones, formed by heating amino acids; the tautomeric enol forms are known as lactims.
Context around Lactam
- Average sentence length in these examples: 22.4 words
- Position in the sentence: 4 start, 10 middle, 6 end
- Sentence types: 20 statements, 0 questions, 0 exclamations
Corpus analysis for Lactam
- In this selection, "lactam" usually appears in the middle of the sentence. The average example has 22.4 words, and this corpus slice is mostly made up of statements.
- Around the word, beta, antibiotics, antibiotic and ring stand out and add context to how "lactam" is used.
- Recognizable usage signals include with β lactam antibiotics and a β lactam antibiotic. That gives this page its own corpus information beyond isolated example sentences.
- By corpus frequency, "lactam" sits close to words such as aarons, abra and accelerations, which helps place it inside the broader word index.
Example types with lactam
The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:
Gram negative bacteria are not generally susceptible to Beta-lactam antibiotics. (11 words)
As a result, the bactericidal action of β-lactam antibiotics is further enhanced. (13 words)
Both hydrolyse all β-lactams except monobactams, and evade all β-lactam inhibitors. (13 words)
Allergy/hypersensitivity Immunologically mediated adverse reactions to any β-lactam antibiotic may occur in up to 10% of patients receiving that agent (a small fraction of which are truly IgE-mediated allergic reactions, see amoxicillin rash ). (36 words)
The image shows that the thiazolidine ring and fused four-membered β-lactam are not in the same plane The term " penam " is used to describe the common core skeleton of a member of the penicillins. (36 words)
At first, β-lactam antibiotics were mainly active only against Gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various Gram-negative organisms has increased their usefulness. (33 words)
Example sentences (20)
At first, β-lactam antibiotics were mainly active only against Gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various Gram-negative organisms has increased their usefulness.
Modes of resistance By definition, all β-lactam antibiotics have a β-lactam ring in their structure.
Resistance to non-beta-lactam antibiotics is common in strains making any of these enzymes, such that alternative options for non-beta-lactam therapy need to be determined by direct susceptibility testing.
This figure outlines the different methods of β-lactam closure among the various classes of β-lactam compounds.
A Jarisch-Herxheimer reaction may occur after initial treatment of a spirochetal infection such as syphilis with a β-lactam antibiotic.
Allergy/hypersensitivity Immunologically mediated adverse reactions to any β-lactam antibiotic may occur in up to 10% of patients receiving that agent (a small fraction of which are truly IgE-mediated allergic reactions, see amoxicillin rash ).
Altered PBPs do not necessarily rule out all treatment options with β-lactam antibiotics.
As a result, the bactericidal action of β-lactam antibiotics is further enhanced.
Both hydrolyse all β-lactams except monobactams, and evade all β-lactam inhibitors.
Clavulanic acid Amoxicillin The production of a β-lactamase by a bacterium does not necessarily rule out all treatment options with β-lactam antibiotics.
Escherichia coli bacteria on the right are sensitive to two beta-lactam antibiotics, and do not grow in the semi-circular regions surrounding the antibiotics.
Gram negative bacteria are not generally susceptible to Beta-lactam antibiotics.
In the absence of β-lactam antibiotics, the bacterial cell wall plays an important role in bacterial reproduction.
It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics.
Mechanism of action Ampicillin is in the penicillin group of beta-lactam antibiotics and is part of the aminopenicillin family.
Mode of action Penicillin and most other β-lactam antibiotics act by inhibiting penicillin-binding proteins, which normally catalyze cross-linking of bacterial cell walls.
Most nylons are made from the reaction of a dicarboxylic acid with a diamine (e.g. PA66) or a lactam or amino acid with itself (e.g. PA6).
The image shows that the thiazolidine ring and fused four-membered β-lactam are not in the same plane The term " penam " is used to describe the common core skeleton of a member of the penicillins.
The structural similarity between β-lactam antibiotics and d -alanyl- d -alanine facilitates their binding to the active site of PBPs.
The β-lactam nucleus of the molecule irreversibly binds to ( acylates ) the Ser 403 residue of the PBP active site.