Macrophages in a sentence

Paradoxically, macrophages can promote tumor growth citation when tumor cells send out cytokines that attract macrophages, which then generate cytokines and growth factors that nurture tumor development.

Macrophages are search-and-destroy blood cells, globular in appearance.

Lead author, postdoctoral fellow Dr Jackie Bader, added: “Macrophages are thought of as being like a garbage truck: They clean up the mess.

The team found that berry-flavored vapes can restrict alveolar macrophages (AMs), which protect the lower respiratory tract.

In addition, the team observed that particulates from both sources caused the macrophages to produce molecules in the immune system which drive inflammation.

The former is a protein on the surface of tumors that sends out a “don’t eat me” signal to macrophages, a type of immune cell.

TNF is a proinflammatory cytokine mainly produced by activated macrophages, natural killer cells and T lymphocytes, which is involved in inflammatory and immune responses.

Dixit’s lab had earlier found that the immune cells needed for the fat-burning process—called macrophages—were still active, but their overall numbers declined as belly fat increased with ageing.

The first applications of the platform, developed in collaboration with the University of Pennsylvania, are autologous chimeric antigen receptor (CAR)-macrophages for the treatment of solid tumors.

When combined, FSI-174 sends a positive signal to macrophages to target blood forming stem cells for removal and magrolimab disengages inhibitory signals that block phagocytosis.

When tissue is damaged, one of the body's first inflammatory immune-system responders are macrophages, cells which are commonly thought of as "construction workers" that clear away damaged tissue debris and initiate repair.

Cytokine signals produced by helper T cells enhance the microbicidal function of macrophages and the activity of killer T cells.

Depending on the antigen, the binding may impede the biological process causing the disease or may activate macrophages to destroy the foreign substance.

Dispersed cells are found to be highly virulent against macrophages and Caenorhabditis elegans, but highly sensitive towards iron stress, as compared with planktonic cells.

HIV-1 entry to macrophages and CD4 + T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on the target cells and also with chemokine coreceptors.

In addition, a combination of hypoxia in the tumor and a cytokine produced by macrophages induces tumor cells to decrease production of a protein that blocks metastasis and thereby assists spread of cancer cells.

Indeed, macrophages play a key role in several critical aspects of HIV infection.

In tonsils and adenoids of HIV-infected patients, macrophages fuse into multinucleated giant cells that produce huge amounts of virus.

It occurs when the macrophages of an individual's own immune system damage the myelin sheaths that insulate the axon of the nerve.

Once in the lymph nodes, the spores germinate into active bacilli that multiply and eventually burst the macrophages, releasing many more bacilli into the bloodstream to be transferred to the entire body.