Microtubule in a sentence

In contrast, heavy water promotes microtubule polymer stability. citation Proteins that interact with microtubules Microtubule-associated proteins (MAPs) main MAPs have been shown to play a crucial role in the regulation of microtubule dynamics in-vivo.

Suppression of microtubule dynamics by tubulin mutations or by drug treatment have been shown to inhibit cell migration. citation Both microtubule stabilizers and destabilizers can suppress microtubule dynamics.

Anti-microtubule agents are plant -derived chemicals that block cell division by preventing microtubule function.

ATP hydolysis in these domains is coupled to movement along the microtubule via the microtubule-binding domains.

GTP-bound tubulin can begin adding to the tip of the microtubule again, providing a new cap and protecting the microtubule from shrinking.

It has anti-microtubule activity, and its mechanism is similar to that of vinca alkaloids in that they bind to tubulin, inhibiting microtubule formation.

Since tubulin adds onto the end of the microtubule in the GTP-bound state, a cap of GTP-bound tubulin is proposed to exist at the tip of the microtubule, protecting it from disassembly.

Structure of a microtubule. The ring shape depicts a microtubule in cross-section, showing the 13 protofilaments surrounding a hollow center.

The axoneme of primary cilia typically has a ring of nine outer microtubule doublets (called a 9+0 axoneme), and the axoneme of a motile cilium has two central microtubule singlets in addition to the nine outer doublets (called a 9+2 axoneme).

The drugs that can alter microtubule dynamics include: * The cancer-fighting taxane class of drugs ( paclitaxel (taxol) and docetaxel ) block dynamic instability by stabilizing GDP-bound tubulin in the microtubule.

The phragmoplast is a microtubule structure typical for higher plants, whereas some green algae use a phycoplast microtubule array during cytokinesis.

Thus, even when hydrolysis of GTP reaches the tip of the microtubule, there is no depolymerization and the microtubule does not shrink back.

Unlike other tubulin-targeting drugs such as colchicine that inhibit microtubule assembly, paclitaxel stabilizes the microtubule polymer and protects it from disassembly.

Vinca alkaloids and taxanes are the two main groups of anti-microtubule agents, and although both of these groups of drugs cause microtubule dysfunction, their mechanisms of action are completely opposite.

A kinesin molecule bound to a microtubule.

A kinetochore is a proteinaceous microtubule-binding structure that forms on the chromosomal centromere during late prophase.

Anti-microtubule agents Vinca alkaloids prevent the assembly of microtubules, whereas taxanes prevent their disassembly.

Basal bodies originate from and have a substructure similar to that of centrioles, with nine peripheral microtubule triplets (see structure at bottom center of image).

During the microtubule-based transport to the nucleus, the viral single-strand RNA genome is transcribed into double-strand DNA, which is then integrated into a host chromosome.

Functions Cell migration Microtubule plus ends are often localized to particular structures.