Mutations in a sentence

Mutations accumulate as the virus makes more copies of itself; in that sense, it’s only natural that we’ll see more mutations of the coronavirus over time.

A mutagen therefore produces signature mutations plus non-informative mutations.

Slowing metabolic rate can prevent detrimental effects of genetic mutations: Finding appears to be universal across hundreds of tested mutations.

Two wrongs don't make a right, but in the case of genetic mutations, having two mutations in the same gene could be better than having either one individually.

When mutation signature mutations are seen in a collection of tumors, the carcinogen's noninformative mutations must be there as well!

Another possible cause of microsatellite mutations are point mutations, where only one nucleotide is incorrectly copied during replication.

As such, mutations in the DBD are recessive loss-of-function mutations.

Beneficial mutations Although mutations that cause changes in protein sequences can be harmful to an organism, on occasions the effect may be positive in a given environment.

By effect on function seeAlso * Loss-of-function mutations, also called inactivating mutations, result in the gene product having less or no function (being partially or wholly inactivated).

Initially, the ability of radiation and chemical mutagens to cause mutation was exploited to generate random mutations, but later techniques were developed to introduce specific mutations.

In one study, three of eight de novo mutations occurred in the postzygotic stage, leading to the estimate that up to one-third of de novo mutations result in somatic mosaicism.

Measuring this rate is important in predicting the rate at which people may develop cancer. citation Point mutations may arise from spontaneous mutations that occur during DNA replication.

Nonstop mutations differ from nonsense mutations in that they do not create a stop codon but, instead, delete one.

Oncogene mutations, in contrast, generally involve a single allele because they are gain-of-function mutations.

Spontaneous mutations are very rare, and advantageous mutations are even rarer.

Targeting p53 and Myc proteins with drugs gave positive results on mice with CML. citation citation Experimental analysis of p53 mutations Most p53 mutations are detected by DNA sequencing.

These are not related to ATP7B mutations: for example, ICC has been linked to mutations in the KRT8 and the KRT18 gene.

This domain is inherently prone to misfolding, while pathological mutations in TDP-43 have been found to increase this propensity to misfold, explaining the presence of these mutations in familial cases of ALS.

This occurs partly because random mutations arise in the genome of an individual organism, and offspring can inherit such mutations.

Advances in genomics and molecular diagnostics enable the identification of specific genetic mutations, allowing for targeted therapies and minimizing side effects.