Nmda in a sentence

Application of glutamate or NMDA can evoke CSD, whereas NMDA receptor antagonists (but not other glutamate receptor subtype antagonists) have been shown to inhibit CSD in a variety of different preparations ().

Dextromethorphan has been noted to slow the development of tolerance to opioids and exert additional analgesia by acting upon the NMDA receptors; some analgesics such as methadone and ketobemidone and perhaps piritramide have intrinsic NMDA action.

Doctors eventually found Kertisha was suffering from anti-NMDA receptor encephalitis, wherein the body fights its own brain cells.

Importantly, spatiotemporal deletion of the obligatory GluN1 subunit of the NMDA receptor in the PVN attenuates hypertension in males ().

Instead, as she recounted in “,” her best-selling 2012 memoir about her ordeal, she was eventually found to have a rare — or at least newly discovered — neurological disease: anti-NMDA-receptor autoimmune encephalitis.

Slowpressor angiotensin II hypertension and concomitant dendritic NMDA receptor trafficking in estrogen receptor beta-containing neurons of the mouse hypothalamic paraventricular nucleus are sex and age dependent.

Susanna was suffering because the right side of her brain was inflamed due to an auto-immune disease called anti-NMDA receptor encephalitis.

Alcohol inhibits glutamate (a major excitatory neurotransmitter in the nervous system) neurotransmission by reducing the effectiveness at the NMDA receptor, which is related to memory loss associated with intoxication.

Also, due to NMDA antagonism, the user may experience all the psychedelic effects present in classical dissociatives such as ketamine in forms of thought loops and feeling of mind being disconnected from one's body.

Due to its activity at the NMDA receptor, it may be more effective against neuropathic pain; for the same reason, tolerance to the analgesic effects may be lesser compared to other opioids.

Excessive glutamate activity is believed to be involved in catatonia; when first-line treatment options fail, NMDA antagonists such as amantadine or memantine are used.

However, the effects of dextrorphan and dextromethorphan, and other NMDA receptor antagonists, on dopamine levels is a disputed subject.

Increased NMDA receptors may point to the involvement of glutamate dopamine interactions in schizophrenia.

Methadone has been shown to reduce neuropathic pain in rat models, primarily through NMDA antagonism.

NMDA receptors do not function without both ligands present.

NMDA receptors have a very important role in modulating long term excitation and memory formation.

PCP's rewarding and reinforcing effects are at least partly mediated by blocking the NMDA receptors in the glutamatergic inputs to D1-type medium spiny neurons in the nucleus accumbens.

Psychotropic agents Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and other α 2 -adrenoreceptor agonists, and mexiletine and other local anaesthetic analogues.

The function of NMDA receptors is dependant on Glycine receptor binding as a co-agonist within the channel pore.

The Headaches, Chp. 28, pp. 269–72 There are a number of explanations for its occurrence including activation of NMDA receptors leading to calcium entering the cell.