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How do you use Nucleophile in a sentence? See 10+ example sentences showing how this word appears in different contexts, plus the exact meaning.

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Nucleophile in a sentence

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Nucleophile | Nucleophiles

Nucleophile meaning

A compound or functional group that is attractive to centres of positive charge, and donates electrons, especially donating an electron pair to an electrophile to form a bond.

Using Nucleophile

  • The main meaning on this page is: A compound or functional group that is attractive to centres of positive charge, and donates electrons, especially donating an electron pair to an electrophile to form a bond.
  • In the example corpus, nucleophile often appears in combinations such as: as nucleophile, the nucleophile.

Context around Nucleophile

  • Average sentence length in these examples: 21.9 words
  • Position in the sentence: 3 start, 6 middle, 5 end
  • Sentence types: 14 statements, 0 questions, 0 exclamations

Often before:

reactive 1× good 1×

Often after:

acceptor 1× giving 1× yielding 1× donor 1× strength 1× attacks 1× may 1×

Sentence patterns with Nucleophile

These short patterns come directly from the example sentences and show how the word is often embedded:

a good nucleophile donor number 1× as a nucleophile and bind 1× as a nucleophile giving glutamine 1× as a nucleophile nu and 1× as a nucleophile while an 1× as the nucleophile because they 1× as the nucleophile yielding 2 1× from the nucleophile attacks the 1×

Sentence openings and endings

Common sentence openings:

for instance phosgene 1× formation of amino 1× halogens while the 1× here sodium amide 1× joule p 130 1× longwitz and werner 1×

Common sentence endings:

affinity of atoms 1× an electron pair 1× and easily obtainable 1× and inorganic phosphate 1× and polyurethane plastics 1× are good nucleophiles 1×

Words around Nucleophile

Just before it in the word index:

nucleons 36 nucleon 31 nucleomorph 3 nucleolus 12 nucleolar 3 nucleogenic 2

Just after it in the word index:

nucleophiles 13 nucleophilic 31 nucleophilicity 3 nucleoplasm 2 nucleoporins 4 nucleoprotein 3

Similar in corpus frequency:

aaronson 18 abai 18 abass 18 abatements 18 abdulfatah 18 abebe 18

Corpus analysis for Nucleophile

  • In this selection, "nucleophile" usually appears in the middle of the sentence. The average example has 21.9 words, and this corpus slice is mostly made up of statements.
  • Around the word, reactive, good, acceptor, giving and yielding stand out and add context to how "nucleophile" is used.
  • Recognizable usage signals include a good nucleophile donor number and as a nucleophile and bind. That gives this page its own corpus information beyond isolated example sentences.
  • By corpus frequency, "nucleophile" sits close to words such as aaronson, abai and abass, which helps place it inside the broader word index.

Example types with nucleophile

The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:

Short example sentences

Nucleophilic describes the affinity of a nucleophile to the nuclei. (10 words)

Here, sodium amide is used as the nucleophile yielding 2-aminopyridine. (11 words)

Under basic conditions, hydroxide acts as a nucleophile, while an alkoxide is the leaving group. (15 words)

Longer example sentences

Formation of amino acids Glutamine is synthesized from glutamate by glutamine synthetase, which utilizes an ATP to form glutamyl phosphate; this intermediate is attacked by ammonia as a nucleophile giving glutamine and inorganic phosphate. (34 words)

It is this deprotonation that allows the serine side chain to act as a nucleophile and bind to the electron-deficient carbonyl carbon of the protein main chain. (28 words)

For instance, phosgene is a highly reactive nucleophile acceptor, which makes it an excellent reagent for polymerizing diols and diamines to produce polycarbonate and polyurethane plastics. (26 words)

Example sentences (14)

Longwitz and Werner note that alcohols are typically used as the nucleophile because they are inexpensive and easily obtainable.

For instance, phosgene is a highly reactive nucleophile acceptor, which makes it an excellent reagent for polymerizing diols and diamines to produce polycarbonate and polyurethane plastics.

Formation of amino acids Glutamine is synthesized from glutamate by glutamine synthetase, which utilizes an ATP to form glutamyl phosphate; this intermediate is attacked by ammonia as a nucleophile giving glutamine and inorganic phosphate.

Halogens While the halogens aren't nucleophilic in their diatomic form (i.e. I 2 is not a nucleophile), their anions are good nucleophiles.

Here, sodium amide is used as the nucleophile yielding 2-aminopyridine.

It is this deprotonation that allows the serine side chain to act as a nucleophile and bind to the electron-deficient carbonyl carbon of the protein main chain.

Joule, p. 130 Nucleophilic substitutions In contrast to benzene, pyridine efficiently supports several nucleophilic substitutions, and is regarded as a good nucleophile ( donor number 33.1).

Nucleophilic describes the affinity of a nucleophile to the nuclei.

Advertentie

Nucleophilicity, sometimes referred to as nucleophile strength, refers to a substance's nucleophilic character and is often used to compare the affinity of atoms.

The bottom panel shows 2-step hydrolysis where a residue within the enzyme is activated to act as a nucleophile (Nu) and attack the substrate.

The electron pair from the nucleophile attacks the substrate forming a new bond, while the leaving group departs with an electron pair.

The nucleophile may be electrically neutral or negatively charged, whereas the substrate is typically neutral or positively charged.

The two main types are electrophilic aromatic substitution when the active reagent is an electrophile and nucleophilic aromatic substitution when the reagent is a nucleophile.

Under basic conditions, hydroxide acts as a nucleophile, while an alkoxide is the leaving group.

Advertentie

Common combinations with nucleophile

These word pairs occur most frequently in English texts:

Frequently asked questions

How do you use "nucleophile" in a sentence?
An example: "Longwitz and Werner note that alcohols are typically used as the nucleophile because they are inexpensive and easily obtainable." This page contains 10+ example sentences with the word "nucleophile" from authentic English texts.
What does "nucleophile" mean?
Nucleophile means: A compound or functional group that is attractive to centres of positive charge, and donates electrons, especially donating an electron pair to an electrophile to form a bond.
How many example sentences with "nucleophile" are there?
Voorbeeldzinnen.info contains at least 10+ example sentences with "nucleophile", drawn from a database of millions of English sentences.