How do you use Paclitaxel in a sentence? See 10+ example sentences showing how this word appears in different contexts, plus the exact meaning.
Paclitaxel in a sentence
Paclitaxel meaning
A taxane antineoplastic drug C₄₇H₅₁NO₁₄ originally isolated from the bark of the Pacific yew, Taxus brevifolia, but now typically derived as a semisynthetic product of the English yew; it interferes with microtubule function and inhibits cell division, and is used in the treatment of some cancers, especially those of the breast and ovary.
Using Paclitaxel
- The main meaning on this page is: A taxane antineoplastic drug C₄₇H₅₁NO₁₄ originally isolated from the bark of the Pacific yew, Taxus brevifolia, but now typically derived as a semisynthetic product of the English yew; it interferes with microtubule function and inhibits cell division, and is used in the treatment of some cancers, especially those of the breast and ovary.
- In the example corpus, paclitaxel often appears in combinations such as: paclitaxel is.
Context around Paclitaxel
- Average sentence length in these examples: 19.3 words
- Position in the sentence: 6 start, 6 middle, 3 end
- Sentence types: 15 statements, 0 questions, 0 exclamations
Corpus analysis for Paclitaxel
- In this selection, "paclitaxel" usually appears near the start of the sentence. The average example has 19.3 words, and this corpus slice is mostly made up of statements.
- Around the word, moreover, insulin, beginning, efforts, treatment and produced stand out and add context to how "paclitaxel" is used.
- Recognizable usage signals include 1 insulin paclitaxel it hindered and almost all paclitaxel produced was. That gives this page its own corpus information beyond isolated example sentences.
- By corpus frequency, "paclitaxel" sits close to words such as aaaa, abductees and abdulahi, which helps place it inside the broader word index.
Example types with paclitaxel
The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:
Paclitaxel is shown as yellow stick. (6 words)
The active stereoisomer is (−)-paclitaxel (shown here). (7 words)
The bark is peeled and processed to provide paclitaxel. (9 words)
In general, in vitro assays involving microtubules, such as motility assays, rely on paclitaxel to maintain microtubule integrity in the absence of the various nucleating factors and other stabilizing elements found in the cell. (34 words)
As noted, by 1992 extensive efforts were underway to accomplish the total synthesis of paclitaxel, efforts motivated by the desire to generate new chemical understanding rather than to achieve practical commercial production. (32 words)
The drugs that can alter microtubule dynamics include: * The cancer-fighting taxane class of drugs ( paclitaxel (taxol) and docetaxel ) block dynamic instability by stabilizing GDP-bound tubulin in the microtubule. (30 words)
Example sentences (15)
Moreover, Paclitaxel has been used in vitro to inhibit insulin fibrillation; in a molar ratio of 10:1 (insulin:paclitaxel), it hindered insulin fibrillation near 70%.
Allergies to drugs such as cyclosporine, teniposide and drugs containing polyoxyethylated castor oil may indicate increased risk of adverse reactions to paclitaxel.
As noted, by 1992 extensive efforts were underway to accomplish the total synthesis of paclitaxel, efforts motivated by the desire to generate new chemical understanding rather than to achieve practical commercial production.
Dexamethasone is given prior to beginning paclitaxel treatment to mitigate some of the side effects.
From 1967 to 1993, almost all paclitaxel produced was derived from bark from the Pacific yew, the harvesting of which kills the tree in the process.
In general, in vitro assays involving microtubules, such as motility assays, rely on paclitaxel to maintain microtubule integrity in the absence of the various nucleating factors and other stabilizing elements found in the cell.
Paclitaxel is shown as yellow stick.
Paclitaxel is then extracted directly, purified by chromatography and isolated by crystallization.
Paclitaxel's mechanism of action involves interference with the normal breakdown of microtubules during cell division.
Paclitaxel-treated cells have defects in mitotic spindle assembly, chromosome segregation, and cell division.
The active stereoisomer is (−)-paclitaxel (shown here).
The bark is peeled and processed to provide paclitaxel.
The compound was then developed commercially by Bristol-Myers Squibb (BMS), who had the generic name assigned as "paclitaxel".
The drugs that can alter microtubule dynamics include: * The cancer-fighting taxane class of drugs ( paclitaxel (taxol) and docetaxel ) block dynamic instability by stabilizing GDP-bound tubulin in the microtubule.
Unlike other tubulin-targeting drugs such as colchicine that inhibit microtubule assembly, paclitaxel stabilizes the microtubule polymer and protects it from disassembly.
Common combinations with paclitaxel
These word pairs occur most frequently in English texts:
- paclitaxel is 2×