Phage in a sentence

Life cycle Infection Lambda phage J protein interaction with the LamB porin Lambda phage is a non-contractile tailed phage, meaning during an infection event it cannot 'force' its DNA through a bacterial cell membrane.

During infection, the phage particle recognizes and binds to its host, E. coli, causing DNA in the head of the phage to be ejected through the tail into the cytoplasm of the bacterial cell.

Methods and results Structural overview of T2 phage Hershey and Chase needed to be able to examine different parts of the phages they were studying separately, so they needed to isolate the phage subsections.

Retroviral INs are not to be confused with phage integrases, such as λ phage integrase (Int) (see site-specific recombination ).

Some lytic phages undergo a phenomenon known as lysis inhibition, where completed phage progeny will not immediately lyse out of the cell if extracellular phage concentrations are high.

The phage genes expressed in this dormant state code for proteins that repress expression of other phage genes (such as the structural and lysis genes) in order to prevent entry into the lytic cycle.

They concluded that the protein protected the RNA from RNAse, but that once the two were separated and the phage was inactivated, the DNAse could hydrolyze the phage DNA.

Until now, no phage therapy has been licensed for therapeutic use in the UK, although they have been used in isolated cases as "compassionate treatments of last resort" in patients with otherwise incurable infections.

A phage library expressing all possible human antibodies (single chain) is available for screening.

But sometimes, the phage DNA gets incorporated into the bacterial host’s chromosome instead, becoming a “prophage”.

Increasing demand for our phage therapies in single-patient expanded access cases could result in significant costs to us.

We intend for the phage to be engineered for a wide host range, and to express anti-biofilm and antimicrobial payloads.

The phage is now a potentially potent weapon against these so-called superbugs.

Phage display produces antibodies that can neutralise toxins, counteract autoimmune diseases and cure metastatic cancer.

All of the known temperate phages employ one of only three different systems for their lysogenic cycle: lambda-like integration/excision, Mu-like transposition or the plasmid-like partitioning of phage N15.

An altogether different phage type, the filamentous phages, make the host cell continually secrete new virus particles.

An example of a bacteriophage known to follow the lysogenic cycle and the lytic cycle is the phage lambda of E. coli.

Animals are first treated with suspected mutagen, the mouse DNA is then isolated and the phage segment recovered and used to infect E. coli.

As soon as the cell is destroyed, the phage progeny can find new hosts to infect.

Both Int and IHF bind to attP and form an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA.