Phosphorylation in a sentence

Finally, the peptide side chains can also be modified covalently, e.g., * phosphorylation :Aside from cleavage, phosphorylation is perhaps the most important chemical modification of proteins.

Phosphorylation functions as an extremely vital component of glycolysis, for it helps in transport, control and efficiency. citation Signaling networks Elucidating complex signaling pathway phosphorylation events can be difficult.

Serine/threonine/tyrosine phosphorylation Addition of a negatively charged phosphate group can lead to major changes in protein structure, leading to the well-characterised role of phosphorylation in controlling protein function.

Tyrosine phosphorylation is relatively rare but is at the origin of protein phosphorylation signaling pathways in most of the eukaryotes.

While protein phosphorylation is a cell-wide regulatory mechanism, recent quantitative proteomics studies have shown that phosphorylation preferentially targets nuclear proteins.

The validated phosphorylation sites were found to be involved in actin regulation, which has been proposed as a novel mechanism for inhibiting resistance development.

But, when dysfunctional, tyrosine phosphorylation can also turn on the uncontrolled cell growth that leads to cancer.

After the phosphorylation, the first degrading enzyme, beta-amylase (BAM) can attack the glucose chain at its non-reducing end.

Also in the 1970s, the term multisite phosphorylation was coined in response to the discovery of proteins that are phosphorylated on two or more residues by two or more kinases.

Antibodies bind to and detect phosphorylation-induced conformational changes in the protein.

A phosphorylated serine residue Phosphorylation is the addition of a phosphate group (PO 4 3− ) to a molecule.

A subfamily of HADs, the Eyes Absent Family (Eya), are also transcription factors and can therefore regulate their own phosphorylation and that of transcriptional cofactor/s, and contribute to the control of gene transcription.

As with phosphorylation, sulfation adds a negative charge to a previously neutral site.

Because protein phosphorylation is one of the most-studied protein modifications, many "proteomic" efforts are geared to determining the set of phosphorylated proteins in a particular cell or tissue-type under particular circumstances.

Being one of the major regulatory mechanisms in signal transduction - cell growth, differentiation, migration and metabolic homeostasis are cellular processes maintained by tyrosine phosphorylation.

But the speed at which ATP is produced in this manner is about 100 times that of oxidative phosphorylation.

Cyanide poisoning Histotoxic hypoxia results when the quantity of oxygen reaching the cells is normal, but the cells are unable to use the oxygen effectively, due to disabled oxidative phosphorylation enzymes.

Dynamins polymerize around the neck of an incoming vesicle, and their phosphorylation by c-SRC provides the energy necessary for the conformational change allowing the final "pinching off" from the membrane.

Eugene Kennedy and Albert Lehninger discovered in 1948 that mitochondria are the site of oxidative phosphorylation in eukaryotes.

Eukaryotic aerobic respiration produces approximately 34 additional molecules of ATP for each glucose molecule, however most of these are produced by a vastly different mechanism to the substrate-level phosphorylation in glycolysis.