Prion in a sentence

In this way, the prion acts as a template to guide the misfolding of more proteins into prion form.

This has been shown by attaching the prion domain to a reporter protein, which then aggregates like a known prion.

This modular view of prion behaviour has led to the hypothesis that similar prion domains are present in animal proteins, in addition to PrP.

While incarcerated, he said his client graduated from high school and is working toward to running a construction company once he is released from prison after serving two-thirds of his sentence in prion, which is about 16 years.

Detection and removal challenges — Current blood screening processes do not specifically test for prions, partly because prion diseases are rare and partly due to the technical challenges in detecting prions at low concentrations.

When a bad prion comes into contact with its normal self, it somehow forces it to turn into another misfolded copy.

It is caused by an abnormal protein called a prion.

The evidence comes from a British research project in Papua New Guinea into another prion disease, Kuru — a major cause of death in a group who practised cannibalism.

Creutzfeldt-Jakob is the most common of prion diseases that affect humans and animals.

Most experts believe the infectious agent is something called a prion, a misfolded cellular protein found in the nervous system and lymph tissue.

Now satisfied that its work is done, the prion moves on to the next PrP, showing itself off and spreading the good word about its bad conformation.

Prion diseases are particularly dangerous because defective prions aggregate into stable clumps of protein that the body cannot easily break down, Rodriguez said.

Prion diseases have become a main area of study at the Hamilton labs, which are part of the the National Institutes of Health's National Institute of Allergy and Infectious Diseases.

As in yeast, the prion-like domain of TDP-43 has been shown to be both necessary and sufficient for protein misfolding and aggregation.

But there are also fears—based on animal studies citation —that consuming beef or beef products containing prion particles can also cause the development of classic CJD.

For example, the population at risk of the severe debilitating disease kuru has significant over-representation of an immune variant of the prion protein gene G127V versus non-immune alleles.

Harmful prion proteins can replicate by converting normal proteins into rogue forms. citation Computer viruses reproduce using the hardware and software already present on computers.

However, a model of prion replication must explain both how prions propagate, and why their spontaneous appearance is so rare.

In addition the "protein only" hypothesis fails to provide a molecular explanation for the ability of prion strains to target specific areas of the brain in distinct patterns.

In general, proteins fold into discrete units that perform distinct cellular functions, but some proteins are also capable of forming an infectious conformational state known as a prion.