Retinoic in a sentence

The physiological form of retinoic acid (all-trans-retinoic acid) regulates gene transcription by binding to nuclear receptors known as retinoic acid receptors (RARs) which are bound to DNA as heterodimers with retinoid "X" receptors (RXRs).

Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation.

Stem cell biology Retinoic acid is an influential factor used in differentiation of stem cells to more committed fates, echoing retinoic acid's importance in natural embryonic developmental pathways.

The retinoids (for example, 13-cis-retinoic acid ) constitute a class of chemical compounds chemically related to retinoic acid, and are used in medicine to modulate gene functions in place of this compound.

Vitamin A biosynthesis Biological role Role in embryology Retinoic acid via the retinoic acid receptor influences the process of cell differentiation, hence, the growth and development of embryos.

Action of phorbol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: Relation to the multistep process of differentiation in human epidermal keratinocytes.

The trigger used was retinoic acid, which has the effect of lowering levels of the protein P63 in the cells, leading to stem cell activation.

For instance, over-the-counter products usually include just esters—or compounds derived from retinoic acid—such as retinyl palmitate, retinyl acetate, and retinyl linoleate, which aren’t as potent.

Retinoic acid not only downregulated MYB, but did so within just one hour.

Boundaries for each somite are regulated by retinoic acid (RA) and a combination of FGF8 and WNT3a.

Cells in the embryo respond to retinoic acid differently depending on the amount present.

During development there is a concentration gradient of retinoic acid along the anterior-posterior (head-tail) axis.

However, such rats show infertility (in both male and females) and continued degeneration of the retina, showing that these functions require retinal or retinol, which are interconvertible but which cannot be recovered from the oxidized retinoic acid.

If retinoic acid is not present the last four rhombomeres do not develop.

Retinal, also known as retinaldehyde, can be reversibly reduced to produce retinol or it can be irreversibly oxidized to produce retinoic acid, which then cannot function as the vitamin in the eye.

Retinoic acid has its effects by turning on a differential pattern of Hox genes which encode different homeodomain transcription factors which in turn can turn on cell type specific genes.

Retinoic acid receptors are another subset of nuclear receptors.

Retinoic acid, termed Tretinoin in clinical usage, is used in the treatment of acne and keratosis pilaris in a topical cream.

So the retinoic acid is an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation and controls bilateral symmetry in vertebrates.

This is because cells of this subtype of leukemia are sensitive to agonists of the retinoic acid receptors (RARs).