Somnolence

Okay, and so I think we do see increases in Cmax with increasing dose, I think the major factor that's going to affect the rate of somnolence is going to be a titration rate.

Hence, this data suggests that "feast-induced drowsiness"—or postprandial somnolence —may be the result of a heavy meal rich in carbohydrates, which indirectly increases the production of sleep-promoting melatonin in the brain.

However, the COX enzymes are expressed constitutively in some areas of the CNS, meaning that even limited penetration may cause adverse effects such as somnolence and dizziness.

Inactivating effects – sedating effects such as drowsiness, somnolence and sedation.

Retrograde amnesia and somnolence can result following recovery.