Taxanes

And AR-V7-negative patients fared better when treated with a second ARS inhibitor (19.8 months overall survival) than those on taxanes (12.8 months).

Anti-microtubule agents Vinca alkaloids prevent the assembly of microtubules, whereas taxanes prevent their disassembly.

Taxanes are natural and semi-synthetic drugs.

Taxanes present difficulties in formulation as medicines because they are poorly soluble in water.

Vinca alkaloids and taxanes are the two main groups of anti-microtubule agents, and although both of these groups of drugs cause microtubule dysfunction, their mechanisms of action are completely opposite.