Telomere in a sentence

Multiple proteins binding single- and double-stranded telomere DNA have been identified. citation These function in both telomere maintenance and capping.

Real-time PCR assay involves determining the Telomere-to-Single Copy Gene (T/S)ratio, citation which is demonstrated to be proportional to the average telomere length in a cell.

There are an additional 100-300 kilobases of telomere-associated repeats between the telomere and the rest of the chromosome.

All of these end up affecting gene expression in a negative direction, and shortening the telomere, thus leading to premature aging or death.

For that reason, the scientists who took part in the study decided to title it “Multiple cancer pathways regulate telomere protection”.

In the process, we also found that some molecular pathways that have a role in cancer development also participate in the regulation of telomere maintenance.

Scott and Mark started the study with relatively similar telomere lengths, which is consistent with a strong genetic component.

At the end of each chromosome is a repetitive DNA sequence, called a telomere, that caps the chromosome and protects its ends from deteriorating.

Also, the telomerase activity are unusually high in these cells when isolated from younger women but decline with age. citation Measurement Several techniques are currently employed to assess average telomere length in eukaryotic cells.

A mechanism for telomere elongation or maintenance is one of the key steps in cellular immortalization and can be used as a diagnostic marker in the clinic.

Because eukaryotes have linear chromosomes, DNA replication is unable to reach the very end of the chromosomes, but ends at the telomere region of repetitive DNA close to the ends.

Chromosomal ends might also be processed as breaks in double-strand DNA with chromosome-to-chromosome telomere fusions resulting.

Eukaryotic telomeres normally terminate with 3′ single-stranded-DNA overhang, which is essential for telomere maintenance and capping.

In addition to these stacked structures, telomeres also form large loop structures called telomere loops, or T-loops.

Over time, due to each cell division, the telomere ends become shorter.

Subsequent studies have confirmed a role for recombination in telomere maintenance by ALT (Dunham et al., 2000), however the exact mechanism of this pathway is yet to be determined.

Telomere length varies greatly between species, from approximately 300 base pairs in yeast citation to many kilobases in humans, and usually is composed of arrays of guanine -rich, six- to eight-base-pair-long repeats.

Telomere sequences vary from species to species, but, in general, one strand is rich in G with fewer Cs.

Telomeres form large loop structures called telomere loops, or T-loops.

The Hayflick Limit is the theoretical limit to the number of times a cell may divide until the telomere becomes so short that division is inhibited and the cell enters senescence.