Tolerability in a sentence

Now we intend to evaluate safety, tolerability and preliminary antitumor activity of KO-2806 in a Phase 1 dose escalation study, which we're calling FIT-001.

Pharmacokinetics data dynamic biochemical changes and safety tolerability will serve as the basis for an end of Phase 2 meeting with FDA.

So, it will be very much a data-driven decision as we start to see how the -- what the PK looks like and what the tolerability is like.

This multi-center, open-label trial is intended to evaluate the safety, tolerability, pharmacokinetics antitumor activity and pharmacodynamics of 154 in combination with liposomal doxorubicin.

Unicycive Therapeutics notes that the FDA wants more info on risk assessment and clinical data to discern the tolerability of LDC in patients.

We have demonstrated across multiple candidates in many clinical studies and in thousands of patients that our liver-directed candidates appear to achieve high levels of target engagement and have encouraging safety and tolerability profiles.

With no additional safety or tolerability issues, the findings of the safety study and an earlier pharmacokinetic study will be submitted to the FDA in the course of this month.

By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability.

Overall, the experimental vaccine showed an “acceptable tolerability and safety profile,” Moderna stated.

Besides, the therapy demonstrated manageable safety and favorable tolerability profile in Phase 2 trials.

Results from the ongoing study showed prolonged durable clinical responses, continued favorable tolerability and strong translational data linking the observed clinical benefit with DPX-Survivac’s mechanism of action.

It’s made from partially hydrolyzed guar gum and has a slow fermentation process, which leads to better tolerability (less gas and bloating).

Yes, I'd say we want to see -- continue to see very good safety and tolerability profile as we've seen in the past and basic efficacy.

Secondary endpoints included progression-free survival (PFS), duration of response (DOR), complete response (CR) rate, time to response, safety, and tolerability.

Rather, differences among compounds usually relate to dosing regimens (related to the compound's elimination half-life ), route of administration, and tolerability profile.