Toxicities

As expected with combination chemotherapy, the most common side effects included gastrointestinal and hematologic toxicities, and fatigue.

No unknown adverse events or toxicities were reported that could limit dosing during the studies.

Gastrointestinal toxicities occurred in patients treated with XPOVIO.

No dose limiting toxicities were reported and a maximum tolerated dose (MTD) was not reached.

These results demonstrate that PK of IV administered NP-Act D is slow and sustained for extended period and it is relatively well-tolerated with minimal toxicities.

As previously reported, no dose-limiting toxicities or long-term safety concerns were observed.

As stated, early diagnosis of side effects is of paramount importance as the majority of these toxicities are reversible if properly managed.

In the absence of research on new antituberculous compounds, the health care community was forced to combat MDR TB by dusting off drugs that had long been shelved due to their toxicities and difficult dosing regimens.

Chemotherapy-related toxicities can occur acutely after administration, within hours or days, or chronically, from weeks to years.

Isocyanates are potentially dangerous irritants to the eyes and respiratory tract, despite their relatively low acute toxicities.

Specific chemotherapeutic agents are associated with organ-specific toxicities, including cardiovascular disease (e.

Symptoms associated with both toxicities include nausea, blurred vision, fatigue, weight-loss, menstrual abnormalities etc. Mohsen, S.E., Mckinney, K. and Shanti, M.S. (2008).

These toxicities only occur with preformed (retinoid) vitamin A (such as from liver).

Toxicities have not been reported following low dose exposure to gadolinium ions.

Toxicity is classified into two categories: acute and chronic toxicities.

With an established target exposure for optimized treatment effectiveness with minimized toxicities, dosing can be personalized to achieve target exposure and optimal results for each patient.