View example sentences and word forms for Transactivation.
Transactivation
Transactivation meaning
The activation of something by another entity that has a spatial relationship with it | The activation of a gene by the presence of another at a different locus, especially following infection by a virus
Example sentences (6)
A coactivator protein interacting with the activation function 1 (AF-1) transactivation domain of the androgen receptor may have been deficient in this patient.
Conversely, the steroid-binding domain may act to repress the AR transactivation domain, perhaps due to the AR's unliganded conformation.
In addition, the transactivation and signal-sensing functions are frequently contained within the same domain.
Starting from the N-terminus, there are first the amino-terminal transactivation domains (TAD 1, TAD 2), which are needed to induce a subset of p53 target genes.
The ligand-binding domain is additionally responsible for dimerization of nucleic receptors prior to binding and providing structures for transactivation used for communication with the translational apparatus.
The transactivation domain is encoded by exon 1, and makes up more than half of the AR protein.