Explore Caspase through 10+ example sentences from English, with an explanation of the meaning and related words like protease. Ideal for language learners, writers and word enthusiasts.
Caspase meaning
Any of several intracellular proteolytic enzymes that mediate apoptosis and pyroptosis.
Synonyms of Caspase
Using Caspase
- The main meaning on this page is: Any of several intracellular proteolytic enzymes that mediate apoptosis and pyroptosis.
- Useful related words include: protease, peptidase, proteinase, proteolytic enzyme.
- In the example corpus, caspase often appears in combinations such as: the caspase, caspase knock-out, caspase cascade.
Context around Caspase
- Average sentence length in these examples: 23.8 words
- Position in the sentence: 5 start, 5 middle, 3 end
- Sentence types: 13 statements, 0 questions, 0 exclamations
Corpus analysis for Caspase
- In this selection, "caspase" usually appears near the start of the sentence. The average example has 23.8 words, and this corpus slice is mostly made up of statements.
- Around the word, processed, cascade, family and activity stand out and add context to how "caspase" is used.
- Recognizable usage signals include 3 and caspase 7 pathway and a caspase 8 knock. That gives this page its own corpus information beyond isolated example sentences.
- By corpus frequency, "caspase" sits close to words such as aaaa, abductees and abdulahi, which helps place it inside the broader word index.
Example types with caspase
The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:
A caspase 9 knock-out leads to a severe brain malformation. (11 words)
A caspase 8 knock-out leads to cardiac failure and thus embryonic lethality. (13 words)
Lamin cleavage is sometimes used as a laboratory indicator of caspase activity in assays for early apoptotic activity. (18 words)
However, with the use of cre-lox technology, a caspase 8 knock-out has been created that exhibits an increase in peripheral T cells, an impaired T cell response, and a defect in neural tube closure. (36 words)
Simple explanation of the mechanisms of apoptosis triggered by internal signals (bcl-2), along the caspase-9, caspase-3 and caspase-7 pathway; and by external signals (FAS and TNF), along the caspase 8 pathway. (35 words)
Usually, AMPs are released to fight off bacterial infections when direct contact between skin epidermal cells and occur, and this process is triggered by a reduction in the levels of a protein called caspase-8. (35 words)
Example sentences (13)
Simple explanation of the mechanisms of apoptosis triggered by internal signals (bcl-2), along the caspase-9, caspase-3 and caspase-7 pathway; and by external signals (FAS and TNF), along the caspase 8 pathway.
Apaf-1 is the protein that turns on caspase 9 by cleavage to begin the caspase cascade that leads to apoptosis.
In some types of cells (type I), processed caspase-8 directly activates other members of the caspase family, and triggers the execution of apoptosis of the cell.
There was also observed significant increase in the Bax/Bcl-2 ratio with translocation of proapoptotic Bax to mitochondria and activation of caspase-3.
Usually, AMPs are released to fight off bacterial infections when direct contact between skin epidermal cells and occur, and this process is triggered by a reduction in the levels of a protein called caspase-8.
A caspase 8 knock-out leads to cardiac failure and thus embryonic lethality.
A caspase 9 knock-out leads to a severe brain malformation.
Caspase, an enzyme which plays a role in catalyzing apoptosis, is thought to be activated by the mutated gene through damaging the ubiquitin-protease system.
Finally, a caspase 3 knock-out was characterized by ectopic cell masses in the brain and abnormal apoptotic features such as membrane blebbing or nuclear fragmentation.
However, with the use of cre-lox technology, a caspase 8 knock-out has been created that exhibits an increase in peripheral T cells, an impaired T cell response, and a defect in neural tube closure.
Lamin cleavage is sometimes used as a laboratory indicator of caspase activity in assays for early apoptotic activity.
The caspase proteins are integral parts of the apoptosis pathway, so it follows that knock-outs made have varying damaging results.
The executioner protein is instead activated by the internal stimuli caused by viral infection not a caspase cascade.
Common combinations with caspase
These word pairs occur most frequently in English texts:
- the caspase 4×
- caspase knock-out 4×
- caspase cascade 2×
- of caspase 2×