Protease in a sentence

The natural protease inhibitors are not to be confused with the protease inhibitors used in antiretroviral therapy.

Certain proteins also tend to degrade in the vacuole due to the presence of a breakdown enzyme called protease.

KalVista Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors for diseases with significant unmet need.

A chemically synthesized c-terminal tail is then grafted onto insulin by reverse proteolysis using the inexpensive protease trypsin; typically the lysine on the c-terminal tail is protected with a chemical protecting group to prevent proteolysis.

After complement proteins initially bind to the microbe, they activate their protease activity, which in turn activates other complement proteases, and so on.

Amyloytic enzymes such as amylase aid in the breakdown of starch in the grains to sugar and dextrin, citation while proteolytic enzymes such as protease catalyze the breakdown of proteins into smaller peptides or amino acids.

Bacillus amyloliquefaciens is the source of a natural antibiotic protein barnase (a ribonuclease ), alpha amylase used in starch hydrolysis, the protease subtilisin used with detergents, and the BamH1 restriction enzyme used in DNA research.

Blood clotting (such as thrombin ) and viral polyprotein processing (such as TEV protease ) requires this level of specificity in order to achieve precise cleavage events.

Caspase, an enzyme which plays a role in catalyzing apoptosis, is thought to be activated by the mutated gene through damaging the ubiquitin-protease system.

Degradation and autolysis Proteases, being themselves proteins, are cleaved by other protease molecules, sometimes of the same variety.

For example, env codes for a protein called gp160 that is cut in two by a cellular protease to form gp120 and gp41.

Highly specific proteases such as TEV protease and thrombin are commonly used to cleave fusion proteins and affinity tags in a controlled fashion.

However these drugs can quickly become ineffective due to the fact that the gene sequences that code for the protease and the reverse transcriptase quickly mutate.

Industrial drugs that are designed as protease and reverse transcriptase inhibitors are made such that they target specific sites and sequences within their respective enzymes.

Inside the endosome, the toxin is split by a trypsin-like protease into its individual A and B fragments.

Lipophilic ligands, attached to lipocalin proteins, have been found to possess tumor protease inhibiting properties.

Modifications of primary structure In addition to those listed above, the most important modification of primary structure is peptide cleavage (See: Protease ).

Other natural protease inhibitors are used as defense mechanisms.

Protease inhibitors have also been seen in nature.

Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects.