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Get to know Cftr better with 10+ real example sentences, the meaning.

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Cftr in a sentence

Cftr meaning

Initialism of Cystic fibrosis transmembrane conductance regulator.

Using Cftr

  • The main meaning on this page is: Initialism of Cystic fibrosis transmembrane conductance regulator.
  • In the example corpus, cftr often appears in combinations such as: the cftr, cftr protein, cftr gene.

Context around Cftr

  • Average sentence length in these examples: 24.7 words
  • Position in the sentence: 5 start, 6 middle, 8 end
  • Sentence types: 19 statements, 0 questions, 0 exclamations

Often before:

mild 2× little 1× functional 1× regulator 1× length 1× besides 1×

Often after:

protein 9× gene 7× mutation 1× activity 1× mutations 1× modulate 1×

Sentence patterns with Cftr

These short patterns come directly from the example sentences and show how the word is often embedded:

when the cftr protein is 2× a functional cftr protein 1× cftr not only 1× conductance regulator cftr protein 1× full length cftr protein 1× gene the cftr protein is 1× in the cftr gene and 1× in the cftr gene can 1×

Sentence openings and endings

Common sentence openings:

cf develops when 1× cftr not only 1× cystic fibrosis is 1× for example cystic 1× if testing shows 1× in people with 1×

Common sentence endings:

a blocked channel 1× cftr mutations exist 1× different mutations known 1× functional cftr protein 1× inside the lungs 1× into affected cells 1×

Words around Cftr

Just before it in the word index:

cftc 44 cfta 7 cft 42 cfsp 3 cfsl 5 cfseu 3

Just after it in the word index:

cfts 3 cfu 10 cfvi 3 cfw 2 cfx 5 cfz 3

Similar in corpus frequency:

aaditya 23 aardman 23 abbo 23 aberg 23 aboitiz 23 abovementioned 23

Corpus analysis for Cftr

  • In this selection, "cftr" usually appears near the end of the sentence. The average example has 24.7 words, and this corpus slice is mostly made up of statements.
  • Around the word, mild, little, functional, protein, gene and mutation stand out and add context to how "cftr" is used.
  • Recognizable usage signals include when the cftr protein is and a functional cftr protein. That gives this page its own corpus information beyond isolated example sentences.
  • By corpus frequency, "cftr" sits close to words such as aaditya, aardman and abbo, which helps place it inside the broader word index.

Example types with cftr

The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:

Short example sentences

CF develops when neither allele can produce a functional CFTR protein. (11 words)

Cystic fibrosis is caused by mutations in a gene known as CFTR. (12 words)

Mutations may also lead to fewer copies of the CFTR protein being produced. (13 words)

Longer example sentences

Results from trials have shown limited success as of 2013. citation A small study published in 2015 found a small benefit. citation The focus of much CF gene therapy research is aimed at trying to place a normal copy of the CFTR gene into affected cells. (46 words)

CFTR not only allows chloride ions to be drawn from the cell and into the ASL, but it also regulates another channel called ENac, whichallows sodium ions to leave the ASL and enter the respiratory epithelium. (36 words)

The carboxyl terminal of the protein is anchored to the cytoskeleton by a PDZ domain interaction. citation In addition, evidence is increasing that genetic modifiers besides CFTR modulate the frequency and severity of the disease. (35 words)

Example sentences (19)

It occurs in 10% to 15% of patients with one "severe" and one "mild" CFTR mutation where little CFTR activity still occurs, or where re two "mild" CFTR mutations exist.

Several mutations in the CFTR gene can occur, and different mutations cause different defects in the CFTR protein, sometimes causing a milder or more severe disease.

Trypsinogen levels can be increased in individuals who have a single mutated copy of the CFTR gene (carriers) or, in rare instances, in individuals with two normal copies of the CFTR gene.

Cystic fibrosis is caused by mutations in a gene known as CFTR.

In people with cystic fibrosis, an inherited mutation in the CFTR gene means their channels don’t work as well and cells produce more mucus.

CF develops when neither allele can produce a functional CFTR protein.

CFTR not only allows chloride ions to be drawn from the cell and into the ASL, but it also regulates another channel called ENac, whichallows sodium ions to leave the ASL and enter the respiratory epithelium.

For example, cystic fibrosis is caused by mutations in the CFTR gene, and is the most common recessive disorder in caucasian populations with over 1,300 different mutations known.

Advertentie

However, when the CFTR protein is malfunctioning, these ions cannot flow out of the cell due to a blocked channel.

If testing shows that parent is a CFTR gene mutation carrier, the other parent is tested to calculate the risk that their children will have CF.

It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

Mutations may also lead to fewer copies of the CFTR protein being produced.

One approach is to develop drugs that get the ribosome to overcome the stop codon and synthesize a full-length CFTR protein.

Pathophysiology The CFTR protein is a channel protein that controls the flow of H 2 O and Cl- ions in and out of cells inside the lungs.

Results from trials have shown limited success as of 2013. citation A small study published in 2015 found a small benefit. citation The focus of much CF gene therapy research is aimed at trying to place a normal copy of the CFTR gene into affected cells.

The carboxyl terminal of the protein is anchored to the cytoskeleton by a PDZ domain interaction. citation In addition, evidence is increasing that genetic modifiers besides CFTR modulate the frequency and severity of the disease.

The flow of ions from the cell and into this layer is determined by ion channels such as CFTR.

The product of this gene (the CFTR protein) is a chloride ion channel important in creating sweat, digestive juices, and mucus.

When the CFTR protein is working correctly, ions freely flow in and out of the cells.

Advertentie

Common combinations with cftr

These word pairs occur most frequently in English texts:

Frequently asked questions

How do you use "cftr" in a sentence?
An example: "It occurs in 10% to 15% of patients with one "severe" and one "mild" CFTR mutation where little CFTR activity still occurs, or where re two "mild" CFTR mutations exist." This page contains 10+ example sentences with the word "cftr" from authentic English texts.
What does "cftr" mean?
Cftr means: Initialism of Cystic fibrosis transmembrane conductance regulator.
How many example sentences with "cftr" are there?
Voorbeeldzinnen.info contains at least 10+ example sentences with "cftr", drawn from a database of millions of English sentences.