How do you use Cofactor in a sentence? See 10+ example sentences showing how this word appears in different contexts, including synonyms like compound, plus the exact meaning.
Cofactor meaning
- A contributing factor.
- A substance, especially a coenzyme or a metal, that must be present for an enzyme to function.
- A molecule that binds to and regulates the activity of a protein.
Synonyms of Cofactor
Using Cofactor
- The main meaning on this page is: A contributing factor. | A substance, especially a coenzyme or a metal, that must be present for an enzyme to function. | A molecule that binds to and regulates the activity of a protein.
- Useful related words include: compound, chemical compound.
- In the example corpus, cofactor often appears in combinations such as: as cofactor, the cofactor, cofactor in.
Context around Cofactor
- Average sentence length in these examples: 24.7 words
- Position in the sentence: 3 start, 10 middle, 5 end
- Sentence types: 18 statements, 0 questions, 0 exclamations
Corpus analysis for Cofactor
- In this selection, "cofactor" usually appears in the middle of the sentence. The average example has 24.7 words, and this corpus slice is mostly made up of statements.
- Around the word, transcriptional, important, non, required, thus and fad stand out and add context to how "cofactor" is used.
- Recognizable usage signals include an important cofactor in many and and a cofactor opsin and. That gives this page its own corpus information beyond isolated example sentences.
- By corpus frequency, "cofactor" sits close to words such as aare, aarti and abl, which helps place it inside the broader word index.
Example types with cofactor
The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:
Except for the ancient nitrogenases, all known Mo-using enzymes use this cofactor. (13 words)
They utilise the cofactor PLP ( pyridoxal phosphate ), which functions by stabilising carbanion intermediates. (13 words)
Vitamin K functions as a cofactor for the enzyme that catalyzes the carboxylation of osteocalcin. (15 words)
Lead is able to bind to and interact with many of the same enzymes as these metals but, due to its differing chemistry, does not properly function as a cofactor, thus interfering with the enzyme's ability to catalyze its normal reaction or reactions. (44 words)
A subfamily of HADs, the Eyes Absent Family (Eya), are also transcription factors and can therefore regulate their own phosphorylation and that of transcriptional cofactor/s, and contribute to the control of gene transcription. (34 words)
Fungal prions have helped to suggest mechanisms of conversion that may apply to all prions, though fungal prions appear distinct from infectious mammalian prions in the lack of cofactor required for propagation. (32 words)
Example sentences (18)
Vitamin K functions as a cofactor for the enzyme that catalyzes the carboxylation of osteocalcin.
An enzyme together with the cofactor(s) required for activity is called a holoenzyme (or haloenzyme).
A subfamily of HADs, the Eyes Absent Family (Eya), are also transcription factors and can therefore regulate their own phosphorylation and that of transcriptional cofactor/s, and contribute to the control of gene transcription.
Dihydrobiopterin reductase activity is needed to replenish quinonoid-dihydrobiopterin back into its tetrahydrobiopterin form, which is an important cofactor in many reactions in amino acid metabolism.
Except for the ancient nitrogenases, all known Mo-using enzymes use this cofactor.
Fungal prions have helped to suggest mechanisms of conversion that may apply to all prions, though fungal prions appear distinct from infectious mammalian prions in the lack of cofactor required for propagation.
However, if there is not enough of the PAH enzyme or its cofactor, then phenylalanine can build up in the blood and brain to toxic levels, affecting brain development and function.
Lead is able to bind to and interact with many of the same enzymes as these metals but, due to its differing chemistry, does not properly function as a cofactor, thus interfering with the enzyme's ability to catalyze its normal reaction or reactions.
L -Gulonolactone then reacts with oxygen, catalyzed by the enzyme L -gulonolactone oxidase (which is nonfunctional in humans and other Haplorrhini primates) and the cofactor FAD+.
PLP also plays a cofactor role in releasing selenium from selenohomocysteine to produce hydrogen selenide, which can then be used to incorporate selenium into selenoproteins.
Research has been devoted to the understanding of the possible non-cofactor roles of other derivatives such as ThTP and AThTP.
Severe diseases such as scurvy can result from defects in this hydroxylation, e.g., mutations in the enzyme prolyl hydroxylase or lack of the necessary ascorbate (vitamin C) cofactor.
These various molybdenum cofactor enzymes are vital to the organisms, and molybdenum is a essential element for life in all higher eukaryote organisms, though not in all bacteria.
They are located within the mitochondria and require adrenodoxin as a cofactor (except 21-hydroxylase and 17α-hydroxylase ).
They recognize and cleave DNA at the same site, and they do not use ATP or AdoMet for their activity—they usually require only Mg 2+ as a cofactor.
They utilise the cofactor PLP ( pyridoxal phosphate ), which functions by stabilising carbanion intermediates.
Vitamin C acts as an electron donor for important enzymes : citation Enzymatic cofactor Ascorbic acid performs numerous physiological functions in the human body.
When stimulated by light, rhodopsin splits into a protein and a cofactor: opsin and all-trans-retinal (a form of vitamin A).
Common combinations with cofactor
These word pairs occur most frequently in English texts:
- as cofactor 4×
- the cofactor 4×
- cofactor in 3×
- cofactor required 2×