Histone in a sentence

For example, acetylation of the K14 and K9 lysines of the tail of histone H3 by histone acetyltransferase enzymes (HATs) is generally related to transcriptional competence.

Histone proteins are the basic packer and arranger of chromatin and can be modified by various post-translational modifications to alter chromatin packing ( Histone modification ).

Michael Grunstein citation and David Allis citation found support for this proposal, in the importance of histone acetylation for transcription in yeast and the activity of the transcriptional activator Gcn5 as a histone acetyltransferase.

Protein interactions within the nucleosome The core histone proteins contains a characteristic structural motif termed the "histone fold," which consists of three alpha-helices (α1-3) separated by two loops (L1-2).

Transcription from methylated CpG islands is strongly and heritably repressed. citation Other miRNAs are epigenetically regulated by either histone modifications or by combined DNA methylation and histone modification.

Nicotinamide is a histone deacetylase inhibitor, so has the potential to reawaken not only cells that carry sleeping HIV, but also to activate other random genes in the cell, meaning that unintended effects may occur.

Scientists reveal function of histone variant H2A.

The company's clinical drug candidate includes Pracinostat, an oral available histone deacetylase inhibitor for the treatment of patients with acute myeloid leukemia and myelodysplastic syndrome.

Based on Rodriguez-Paredes and Esteller, Nature, 2011 A huge catalogue of histone modifications have been described, but a functional understanding of most is still lacking.

Because of this, lysine methylation tends to be a very informative mark and dominates the known histone modification functions.

Chromatin is the complex of DNA and the histone proteins with which it associates.

Each core histone possesses a `tail' structure, which can vary in several ways; it is thought that these variations act as "master control switches," which determine the overall arrangement of the chromatin.

Epigenetic Options seeAlso Epigenetics is the study of heritable changes in gene activity that are not caused by changes in the DNA sequence, often a result of environmental or dietary damage to the histone receptors within the cell.

For example, Histone acetylation results in loosening and increased accessibility of chromatin for replication and transcription.

Histone phosphorylation, along with methylation, ubiquitination, sumoylation and acetylation, also regulates access to DNA through chromatin reorganisation.

Histone proteins are among the most highly conserved proteins in eukaryotes, emphasizing their important role in the biology of the nucleus.

Histone proteins are made up of long chains of amino acids.

Histone ubiquitination alters chromatin structure and allows the access of enzymes involved in transcription.

However, it is an excellent mark of active promoters and the level of this histone modification at a gene’s promoter is broadly correlated with transcriptional activity of the gene.

If the amino acids that are in the chain are changed, the shape of the histone might be modified.