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How do you use Proteasome in a sentence? See 10+ example sentences showing how this word appears in different contexts, plus the exact meaning.

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Proteasome in a sentence

Proteasome meaning

A complex protein, found in bacterial, archeal and eukaryotic cells, that breaks down other proteins via proteolysis.

Using Proteasome

  • The main meaning on this page is: A complex protein, found in bacterial, archeal and eukaryotic cells, that breaks down other proteins via proteolysis.
  • In the example corpus, proteasome often appears in combinations such as: the proteasome, proteasome is.

Context around Proteasome

  • Average sentence length in these examples: 21.1 words
  • Position in the sentence: 7 start, 7 middle, 5 end
  • Sentence types: 19 statements, 0 questions, 0 exclamations

Often before:

20s 2× normal 1× 26s 1× first 1× ubiquitin 1×

Often after:

assembled 1× breaks 1× inhibitor 1× inhibitors 1× system 1× subcomponents 1×

Sentence patterns with Proteasome

These short patterns come directly from the example sentences and show how the word is often embedded:

a 20s proteasome the β 1× by the proteasome but rather 1× by the proteasome which provides 1× called the proteasome 1× consider the proteasome for the 1× exposure to proteasome inhibitors 1× of the proteasome above 1× of the proteasome and an 1×

Sentence openings and endings

Common sentence openings:

after a cdk 1× an improved and 1× assembly the assembly 1× bortezomib boronated mg132 1× however some cell 1× however sometimes the 1×

Common sentence endings:

a chemotherapy agent 1× an active complex 1× called the proteasome 1× clpp and clpx 1× coefficient denoted s 1× diverse regulatory activities 1×

Words around Proteasome

Just before it in the word index:

proteases 31 protease 31 proteas 142 protean 13 protea 24 protasiewicz 20

Just after it in the word index:

proteau 2 protect 9.420 protectant 8 protected 3.124 protectees 4 protecting 2.536

Similar in corpus frequency:

aaditya 23 aardman 23 abbo 23 aberg 23 aboitiz 23 abovementioned 23

Corpus analysis for Proteasome

  • In this selection, "proteasome" usually appears near the start of the sentence. The average example has 21.1 words, and this corpus slice is mostly made up of statements.
  • Around the word, 20s, normal, 26s, assembled, breaks and inhibitor stand out and add context to how "proteasome" is used.
  • Recognizable usage signals include a 20s proteasome the β and by the proteasome but rather. That gives this page its own corpus information beyond isolated example sentences.
  • By corpus frequency, "proteasome" sits close to words such as aaditya, aardman and abbo, which helps place it inside the broader word index.

Example types with proteasome

The same corpus examples are grouped by length and sentence type, making it easier to see the contexts in which the word appears:

Short example sentences

Top view of the proteasome above. (6 words)

The 20S proteasome is both ubiquitous and essential in eukaryotes. (10 words)

The proteasome subcomponents are often referred to by their Svedberg sedimentation coefficient (denoted S). (14 words)

Longer example sentences

Ubiquitin—so named because it is found in virtually all types of cells—serves as a flag to mark proteins for degradation in a cellular garbage disposal called the proteasome. (30 words)

However, some cell lines — in particular, primary cultures of quiescent and differentiated cells such as thymocytes and neurons — are prevented from undergoing apoptosis on exposure to proteasome inhibitors. (28 words)

In bacteria that express a 20S proteasome, the β subunits have high sequence identity to archaeal and eukaryotic β subunits, whereas the α sequence identity is much lower. (28 words)

Example sentences (19)

The proteasome assembled with these alternative subunits is known as the immunoproteasome, whose substrate specificity is altered relative to the normal proteasome.

However, sometimes the proteasome breaks down proteins without the help of ubiquitin tags, leading researchers to suspect that there was another, ubiquitin-independent mechanism of protein degradation.

Ubiquitin—so named because it is found in virtually all types of cells—serves as a flag to mark proteins for degradation in a cellular garbage disposal called the proteasome.

This occurs when ubiquitin molecules mark old, defective, and toxic proteins for destruction by the cell’s protein-disposal unit, known as the 26S proteasome.

After a CDK-cyclin complex has performed its function, the associated cyclin is polyubiquitinated and destroyed by the proteasome, which provides directionality for the cell cycle.

An improved and comprehensive understanding of the pathophysiology of the proteasome should lead to clinical applications in the future.

Assembly The assembly of the proteasome is a complex process due to the number of subunits that must associate to form an active complex.

Bortezomib (Boronated MG132), a molecule developed by Millennium Pharmaceuticals and marketed as Velcade, is the first proteasome inhibitor to reach clinical use as a chemotherapy agent.

Advertentie

However, some cell lines — in particular, primary cultures of quiescent and differentiated cells such as thymocytes and neurons — are prevented from undergoing apoptosis on exposure to proteasome inhibitors.

In bacteria that express a 20S proteasome, the β subunits have high sequence identity to archaeal and eukaryotic β subunits, whereas the α sequence identity is much lower.

Malin, another protein mutated in Lafora disease, aids in the degradation of PTG, with assistance from laforin via the ubiquitin proteasome system (UPS).

Many bacteria also possess other homologs of the proteasome and an associated ATPase, most notably ClpP and ClpX.

More recently, more effort has been made to consider the proteasome for the development of novel diagnostic markers and strategies.

Proteins conjugated to UBLs are typically not targeted for degradation by the proteasome but rather function in diverse regulatory activities.

Such activity requires the proteasome to cleave the substrate protein internally, rather than processively degrading it from one terminus.

The 20S proteasome is both ubiquitous and essential in eukaryotes.

The mechanism by which a polyubiquitinated protein is targeted to the proteasome is not fully understood.

The proteasome subcomponents are often referred to by their Svedberg sedimentation coefficient (denoted S).

Top view of the proteasome above.

Advertentie

Common combinations with proteasome

These word pairs occur most frequently in English texts:

Frequently asked questions

How do you use "proteasome" in a sentence?
An example: "The proteasome assembled with these alternative subunits is known as the immunoproteasome, whose substrate specificity is altered relative to the normal proteasome." This page contains 10+ example sentences with the word "proteasome" from authentic English texts.
What does "proteasome" mean?
Proteasome means: A complex protein, found in bacterial, archeal and eukaryotic cells, that breaks down other proteins via proteolysis.
How many example sentences with "proteasome" are there?
Voorbeeldzinnen.info contains at least 10+ example sentences with "proteasome", drawn from a database of millions of English sentences.